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pentobarbital will reduce the extent or effect of abiraterone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will minimize the extent or effect of dapsone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.pentobarbital boosts toxicity of buprenorphine, prolonged